Open AccessThe utility of lesion classification in predicting language and treatment outcomes in chronic stroke-induced aphasia
Author(s) -
Erin L. Meier,
Jeffrey P. Johnson,
Yue Pan,
Swathi Kıran
Publication year - 2019
Publication title -
brain imaging and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.239
H-Index - 50
eISSN - 1931-7565
pISSN - 1931-7557
DOI - 10.1007/s11682-019-00118-3
Subject(s) - aphasia , lesion , stroke (engine) , lateralization of brain function , fractional anisotropy , boston naming test , neuropsychology , white matter , medicine , diffusion mri , audiology , stroke recovery , rehabilitation , psychology , pathology , magnetic resonance imaging , cognition , radiology , physical therapy , psychiatry , mechanical engineering , engineering
Stroke recovery models can improve prognostication of therapy response in patients with chronic aphasia, yet quantifying the effect of lesion on recovery is challenging. This study aimed to evaluate the utility of lesion classification via gray matter (GM)-only versus combined GM plus white matter (WM) metrics and to determine structural measures associated with aphasia severity, naming skills, and treatment outcomes. Thirty-four patients with chronic aphasia due to left hemisphere infarct completed T1-weighted and DTI scans and language assessments prior to receiving a 12-week naming treatment. GM metrics included the amount of spared tissue within five cortical masks. WM integrity was indexed by spared tissue and fractional anisotropy (FA) from four homologous left and right association tracts. Clustering of GM-only and GM + WM metrics via k-medoids yielded four patient clusters that captured two lesion characteristics, size and location. Linear regression models revealed that both GM-only and GM + WM clustering predicted baseline aphasia severity and naming skills, but only GM + WM clustering predicted treatment outcomes. Spearman correlations revealed that without controlling for lesion volume, the majority of left hemisphere metrics were related to language measures. However, adjusting for lesion volume, no relationships with aphasia severity remained significant. FA from two ventral left WM tracts was related to naming and treatment success, independent of lesion size. In sum, lesion volume and GM metrics are sufficient predictors of overall aphasia severity in patients with chronic stroke, whereas diffusion metrics reflecting WM tract integrity may add predictive power to language recovery outcomes after rehabilitation.