Open AccessAn Immunocompetent Model of Pancreatic Cancer Resection and Recurrence
Author(s) -
Bhuwan Giri,
Anthony Ferrantella,
Prateek Sharma,
Tejeshwar Jain,
Harrys K.C. Jacob,
Shrey Modi,
Saba Kurtom,
Pooja Roy,
Vrishketan Sethi,
Sulagna Banerjee,
Nipun B. Merchant,
Sundaram Ramakrishnan,
Ashok K. Saluja,
Vikas Dudeja
Publication year - 2021
Publication title -
journal of gastrointestinal surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.168
H-Index - 126
eISSN - 1873-4626
pISSN - 1091-255X
DOI - 10.1007/s11605-020-04681-9
Subject(s) - medicine , pancreatic cancer , stromal cell , pancreas , immunotherapy , chemotherapy , adenocarcinoma , histology , pancreatic tumor , stroma , cancer , pathology , oncology , immunohistochemistry
Even after surgical resection, most patients with localized pancreatic ductal adenocarcinoma (PDAC) succumb to disease recurrence. Current animal models do not recapitulate this pattern of disease recurrence. Our goal was to develop a clinically relevant, immunocompetent model of PDAC resection to study recurrence and evaluate therapy.