Open AccessInhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma
Author(s) -
Steven I Park,
Carolina P. Lin,
Natalie Ren,
Steven P. Angus,
Dirk P. Dittmer,
Michael B. Foote,
Trevor Parton,
Aadra P. Bhatt,
Yuri Fedoriw,
Daniel Röth,
Marissa L. Cann,
Gary L. Johnson,
Blossom Damania
Publication year - 2019
Publication title -
targeted oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.697
H-Index - 40
eISSN - 1776-260X
pISSN - 1776-2596
DOI - 10.1007/s11523-019-00662-4
Subject(s) - cancer research , medicine , lymphoma , propidium iodide , chemotherapy , vincristine , cyclophosphamide , apoptosis , immunology , programmed cell death , biology , biochemistry
Aberrant Myc expression plays a critical role in various tumors, including non-Hodgkin lymphoma (NHL). Myc-positive lymphoma is clinically aggressive, more resistant to chemotherapy, and associated with high mortality.