Open AccessPerinatal diet influences health and survival in a mouse model of leukemia
Author(s) -
Dushani L. Palliyaguru,
Annamaria Rudderow,
Alex M. Sossong,
Kaitlyn N. Lewis,
Caitlin M. Younts,
Kevin J. Pearson,
Michel Bernier,
Rafael de Cabo
Publication year - 2020
Publication title -
geroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.883
H-Index - 63
eISSN - 2509-2715
pISSN - 2509-2723
DOI - 10.1007/s11357-020-00199-9
Subject(s) - offspring , litter , pregnancy , biology , calorie , physiology , reproduction , endocrinology , genetics , agronomy
The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.