Open AccessArterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice
Author(s) -
Juan Francisco Rodríguez Moreno,
Daniel Escobedo,
Cheresa Calhoun,
Claude Jourdan Le Saux,
HaiChao Han
Publication year - 2020
Publication title -
experimental mechanics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 87
eISSN - 1741-2765
pISSN - 0014-4851
DOI - 10.1007/s11340-020-00666-6
Subject(s) - elastin , pulmonary artery , cardiology , medicine , pulmonary hypertension , arterial stiffness , artery , pathology , blood pressure
Pulmonary artery hypertension (PAH) is a complex disorder that can lead to right heart failure. The generation of caveolin-1 deficient mice (CAV-1 -/- ) has provided an alternative genetic model to study the mechanisms of pulmonary hypertension. However, the vascular adaptations in these mice have not been characterized.