Open AccessLeft Ventricular Geometry, Tissue Composition, and Residual Stress in High Fat Diet Dahl-Salt Sensitive Rats
Author(s) -
Marissa R. Grobbel,
Lik Chuan Lee,
Stephanie W. Watts,
Gregory D. Fink,
Sara Roccabianca
Publication year - 2020
Publication title -
experimental mechanics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 87
eISSN - 1741-2765
pISSN - 0014-4851
DOI - 10.1007/s11340-020-00664-8
Subject(s) - ventricle , medicine , adipose tissue , pathological , endocrinology , residual stress , cardiology , blood pressure , strain (injury) , pathology , materials science , composite material
Hypertension drives myocardial remodeling, leading to changes in structure, composition and mechanical behavior, including residual stress, which are linked to heart disease progression in a gender-specific manner. Emerging therapies are also targeting constituent-specific pathological features. All previous studies, however, have characterized remodeling in the intact tissue, rather than isolated tissue constituents, and did not include sex as a biological variable.