Open AccessPentagalloyl Glucose (PGG) Partially Prevents Arterial Mechanical Changes Due to Elastin Degradation
Author(s) -
Shawn Pavey,
Austin J. Cocciolone,
Anne-Laure Marty,
Humza Ismail,
Jie Z Hawes,
Jessica E. Wagenseil
Publication year - 2020
Publication title -
experimental mechanics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 87
eISSN - 1741-2765
pISSN - 0014-4851
DOI - 10.1007/s11340-020-00625-1
Subject(s) - elastin , biomedical engineering , chemistry , elasticity (physics) , compliance (psychology) , biophysics , materials science , anatomy , medicine , composite material , pathology , biology , psychology , social psychology
Elastic fibers are composed primarily of the protein elastin and they provide reversible elasticity to the large arteries. Degradation of elastic fibers is a common histopathology in aortic aneurysms. Pentagalloyl glucose (PGG) has been shown to bind elastin and stabilize elastic fibers in some in vitro studies and in vivo models of abdominal aortic aneurysms, however its effects on native arteries are not well described.