Open AccessA Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking
Author(s) -
Nourhan Shalaby,
John J. Kelly,
Francisco Martínez Martínez,
Matthew S. Fox,
Qi Qi,
Jonathan D. Thiessen,
Justin Hicks,
Timothy J. Scholl,
John A. Ronald
Publication year - 2022
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-021-01697-8
Subject(s) - reporter gene , sodium iodide symporter , magnetic resonance imaging , positron emission tomography , cancer research , nuclear medicine , chemistry , medicine , gene , symporter , transporter , gene expression , radiology , biochemistry
Reporter gene imaging has been extensively used to longitudinally report on whole-body distribution and viability of transplanted engineered cells. Multi-modal cell tracking can provide complementary information on cell fate. Typical multi-modal reporter gene systems often combine clinical and preclinical modalities. A multi-modal reporter gene system for magnetic resonance imaging (MRI) and positron emission tomography (PET), two clinical modalities, would be advantageous by combining the sensitivity of PET with the high-resolution morphology and non-ionizing nature of MRI.