Open AccessQuantification of SV2A Binding in Rodent Brain Using [18F]SynVesT-1 and PET Imaging
Author(s) -
Pragalath Sadasivam,
Xiaotian T. Fang,
Takuya Toyonaga,
Supum Lee,
Yuping Xu,
Ming-Qiang Zheng,
Joshua Spurrier,
Yiyun Huang,
Stephen M. Strittmatter,
Richard E. Carson,
Zhengxin Cai
Publication year - 2020
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-020-01567-9
Subject(s) - binding potential , cerebellum , nuclear medicine , medicine , neuroscience , pathology , positron emission tomography , biology
Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and neuropsychiatric disorders play a critical role in the drug discovery and development process, a robust, objective, and translational method for quantifying therapeutic drug efficacy in animal models will facilitate the drug development process. In this study, we tested the quantification reliability of the SV2A PET tracer, [ 18 F]SynVesT-1, in a mouse model of AD (APP/PS1) and wild-type controls, and developed a simplified quantification method to facilitate large cohort preclinical imaging studies.