Open AccessThe Roles of ZnT1 and ZnT4 in Glucose-Stimulated Zinc Secretion in Prostate Epithelial Cells
Author(s) -
Su-Tang Lo,
Daniel Parrott,
M. Veronica Clavijo Jordan,
Diya B. Joseph,
Douglas W. Strand,
UGing Lo,
Lin H,
Anza Darehshouri,
A. Dean Sherry
Publication year - 2020
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-020-01557-x
Subject(s) - gene knockdown , lncap , zinc , intracellular , cell culture , bafilomycin , biology , microbiology and biotechnology , flow cytometry , chemistry , secretion , biochemistry , prostate , apoptosis , genetics , organic chemistry , autophagy , cancer
We have previously demonstrated by MRI that high glucose stimulates efflux of zinc ions from the prostate. To our knowledge, this phenomena had not been reported previously and the mechanism remains unknown. Here, we report some initial observations that provide new insights into zinc processing during glucose-stimulated zinc secretion (GSZS) in the immortalized human prostate epithelial cell line, PNT1A. Additionally, we identified the subtypes of zinc-containing cells in human benign prostatic hyperplasia (BPH) tissue to further identify which cell types are likely responsible for zinc release in vivo.