Open AccessPreclinical Assessment of the Effectiveness of Magnetic Resonance Molecular Imaging of Extradomain-B Fibronectin for Detection and Characterization of Oral Cancer
Author(s) -
Ryan Hall,
Nadia Ayat,
Peter Qiao,
Amita Vaidya,
Dan Ma,
Anita Aminoshariae,
Ivan J. Stojanov,
Zheng Rong Lü
Publication year - 2020
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-020-01524-6
Subject(s) - magnetic resonance imaging , immunohistochemistry , fibronectin , pathology , cancer research , cancer , chemistry , cell culture , medicine , microbiology and biotechnology , cell , biology , radiology , biochemistry , genetics
Oral squamous cell carcinoma (OSCC) has not seen a substantial improvement in patient survival despite therapeutic advances, making accurate detection and characterization of the disease a clinical priority. Here, we aim to demonstrate the effectiveness of magnetic resonance imaging (MRI) with the targeted MRI contrast agent MT218 specific to extradomain-B fibronectin (EDB-FN) in the tumor microenvironment for detection and characterization of aggressive OSCC tumors.