Open AccessSynthesis and Application of a Long-Circulating Radiolabeled Peptide for Targeting of Osteosarcoma
Author(s) -
Yesen Li,
Daifeng Li,
Hua Wu,
Jinxiong Huang,
Zhen Cheng
Publication year - 2020
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01468-6
Subject(s) - dota , in vivo , positron emission tomography , pharmacokinetics , peptide , osteosarcoma , chemistry , radionuclide therapy , cancer research , nuclear medicine , medicine , pharmacology , biochemistry , biology , microbiology and biotechnology
The small peptide TMTP1 (NVVRQ) has been proved to target a series of highly metastatic tumor cells. The aim of this study was to develop a new agent based on TMTP1 conjugated with Evans blue (EB), to increase tumor uptake and modify the pharmacokinetic characteristics of the resulting radiolabeled agent.