Open AccessNanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer
Author(s) -
Nicholas E. Wojtynek,
Madeline T. Olson,
Timothy A. Bielecki,
Wei An,
Aaqib M. Bhat,
Hamid Band,
Scott R. Lauer,
Edibaldo Silva-Lopez,
Aaron M. Mohs
Publication year - 2019
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01462-y
Subject(s) - indocyanine green , medicine , breast cancer , radiology , occult , cancer , surgical margin , surgery , pathology , resection , alternative medicine
Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green (ICG)-loaded self-assembled hyaluronic acid (HA) nanoparticles (NanoICG) for solid tumor imaging, which were shown to enhance intraoperative contrast.