Open AccessComparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging
Author(s) -
Christopher Corbett,
Lydia G. Frenzel Sulyok,
Jarrod D. Predina,
Andrew D. Newton,
Mitchell G. Bryski,
Leilei Xia,
Jason Stadanlick,
Michael Shin,
Sakkarapalayam M. Mahalingam,
Philip S. Low,
Sunil Singhal
Publication year - 2019
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01434-2
Subject(s) - stokes shift , autofluorescence , in vivo , flow cytometry , fluorescence , ex vivo , molecular imaging , biophysics , fluorescence lifetime imaging microscopy , chemistry , folate receptor , receptor , microbiology and biotechnology , cancer cell , cancer research , in vitro , medicine , cancer , biology , optics , biochemistry , physics
Intraoperative molecular imaging (IMI) utilizes optical dyes that accumulate within tumors to assist with detection during a cancer operation. IMI can detect disease not visualized preoperatively, as well as positive margins. However, these dyes are limited by autofluorescence, signal reflection, and photon-scatter. We hypothesize that a novel dye with a wide separation between excitation and emission spectra, SS180, would help overcome these obstacles.