Open AccessParamagnetic Fluorinated Nanoemulsions for in vivo F-19 MRI
Author(s) -
Junsung Rho,
Emma Stares,
Stephen Adams,
Deanne Lister,
Benjamin I. Leach,
Eric T. Ahrens
Publication year - 2019
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01415-5
Subject(s) - biocompatibility , in vivo , pulmonary surfactant , chemistry , chelation , dynamic light scattering , chromatography , materials science , nanotechnology , organic chemistry , nanoparticle , biochemistry , microbiology and biotechnology , biology
We aim to develop perfluorocarbon-based nanoemulsions with improved sensitivity for detection of inflammatory macrophages in situ using F-19 MRI. Towards this goal, we evaluate the feasibility of nanoemulsion formulation incorporating a metal chelate in the fluorous phase which shortens the F-19 longitudinal relaxation rate and image acquisition time.