Open AccessAcute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1
Author(s) -
Hui Liu,
Richard Laforest,
Jiwei Gu,
Zonghua Luo,
Lynne A. Jones,
Robert J. Gropler,
Tammie L.S. Benzinger
Publication year - 2019
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01380-z
Subject(s) - tolerability , medicine , biodistribution , toxicity , acute toxicity , pharmacology , dosimetry , pharmacokinetics , bolus (digestion) , effective dose (radiation) , nuclear medicine , adverse effect , biology , in vivo , microbiology and biotechnology
In preclinical studies with rodent models of inflammatory diseases, [ 11 C]CS1P1 has been identified as a promising imaging agent targeting sphingosine-1-phosphate receptor 1 (S1P1) in the central nervous system and other tissues. In preparation for USA Food and Drug Administration (FDA) approval of [ 11 C]CS1P1 for human use, an acute biodistribution study in mice and an acute tolerability and toxicity evaluation in rats were conducted.