Open AccessSemiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Intrapatient and Interpatient Variability of Normal Organ Uptake
Author(s) -
Karine Sahakyan,
Xin Li,
Martin A. Lodge,
Rudolf A. Werner,
Ralph A. Bundschuh,
Lena Bundschuh,
Harshad Kulkarni,
Christiane Schuchardt,
Richard Baüm,
Kenneth J. Pienta,
Martin G. Pomper,
Ashley E. Ross,
Michael A. Gorin,
Steven P. Rowe
Publication year - 2019
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01376-9
Subject(s) - medicine , nuclear medicine , intraclass correlation , positron emission tomography , spleen , repeatability , prostate cancer , pathology , cancer , chemistry , clinical psychology , chromatography , psychometrics
Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging has impacted the management of patients with prostate cancer (PCa) in many parts of the world. PSMA-targeted endoradiotherapies are also being increasingly utilized and for these applications, the radiopharmaceutical distribution in normal organs is particularly important because it may limit the dose that can be delivered to tumors. In this study, we measured both interpatient and intrapatient variability of [ 18 F]DCFPyL uptake in the most relevant normal organs.