Open AccessImaging Sigma-1 Receptor (S1R) Expression Using Iodine-124-Labeled 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine ([124I]IPAG)
Author(s) -
Kishore Gangangari,
András Váradi,
Susruta Majumdar,
Steven M. Larson,
Gavril W. Pasternak,
Nagavarakishore Pillarsetty
Publication year - 2019
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-019-01369-8
Subject(s) - in vivo , biodistribution , lncap , chemistry , ex vivo , positron emission tomography , in vitro , sigma 1 receptor , cancer research , pharmacology , receptor , nuclear medicine , medicine , cancer cell , cancer , agonist , biology , biochemistry , microbiology and biotechnology
Sigma-1 receptors (S1Rs) are overexpressed in almost all human cancers, especially in breast cancers. 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine (IPAG) is a validated high-affinity S1R antagonist. The objective of the current study is to evaluate the potential of iodine-124-labeled IPAG ([ 124 I]IPAG) to image S1R-overexpressing tumors.