Open Access[18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model
Author(s) -
Giacomo Pirovano,
Sheryl Roberts,
Christian Brand,
Patrick L. Donabedian,
Christian Mason,
Paula Demétrio de Souza,
Geoff S. Higgins,
Thomas Reiner
Publication year - 2018
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-018-1288-6
Subject(s) - biodistribution , in vivo , positron emission tomography , ex vivo , preclinical imaging , pet imaging , nuclear medicine , molecular imaging , imaging agent , chemistry , u87 , medicine , cancer research , pharmacology , glioblastoma , biology , microbiology and biotechnology
Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient identification, stratification, and disease monitoring.