Open AccessCorrelation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma
Author(s) -
Ilwoo Park,
Janine M. Lupo,
Sarah J. Nelson
Publication year - 2018
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-018-1275-y
Subject(s) - nuclear medicine , magnetic resonance imaging , perfusion , glioblastoma , gadolinium , cerebral blood volume , voxel , perfusion scanning , magnetic resonance spectroscopic imaging , nuclear magnetic resonance , medicine , chemistry , radiology , cancer research , physics , organic chemistry
The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1- 13 C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM).