Open AccessBiodistribution and Radiation Dosimetry of the Carbonic Anhydrase IX Imaging Agent [18 F]VM4-037 Determined from PET/CT Scans in Healthy Volunteers
Author(s) -
Mohan Doss,
Hartmuth C. Kolb,
Joseph C. Walsh,
Vani P. Mocharla,
Zhihong Zhu,
Michael S. Haka,
R. Katherine Alpaugh,
David Y.T. Chen,
Jinpu Yu
Publication year - 2014
Publication title -
molecular imaging and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 68
eISSN - 1860-2002
pISSN - 1536-1632
DOI - 10.1007/s11307-014-0730-7
Subject(s) - biodistribution , nuclear medicine , medicine , dosimetry , positron emission tomography , effective dose (radiation) , absorbed dose , imaging phantom , kidney , in vivo , biology , microbiology and biotechnology
[(18) F]VM4-037 has been developed as a positron emission tomography (PET) imaging marker to detect carbonic anhydrase IX (CA-IX) overexpression and is being investigated for use as a surrogate marker for tissue hypoxia. The purpose of this study was to determine the biodistribution and estimate the radiation dose from [(18) F]VM4-037 using whole-body PET/CT scans in healthy human volunteers.