Open AccessAge-and Region-Dependent Disposition of Raloxifene in Rats
Author(s) -
Ting Du,
Rongjin Sun,
Imoh Etim,
Zicong Zheng,
Dong Liang,
Ming Hu,
Song Gao
Publication year - 2021
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-021-03084-y
Subject(s) - raloxifene , glucuronidation , bioavailability , pharmacokinetics , duodenum , endocrinology , pharmacology , medicine , glucuronide , chemistry , metabolite , estrogen receptor , microsome , biochemistry , cancer , breast cancer , enzyme
Raloxifene undergoes extensive glucuronidation in the gastrointestinal (GI) tract and the liver. However, the impact of age on raloxifene disposition has never been studied. The purpose of this paper is to determine glucuronidation and Pharmacokinetics (PK) profiles of raloxifene in rats at different ages.