Open AccessGlutathione-Conjugated Hydrogels: Flexible Vehicles for Personalized Treatment of Bacterial Infections
Author(s) -
Karol Sokolowski,
Hai M. Pham,
Eric Wenzler,
Richard A. Gemeinhart
Publication year - 2021
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-021-03057-1
Subject(s) - self healing hydrogels , peg ratio , drug delivery , chemistry , glutathione , meropenem , ethylene glycol , bioavailability , pharmacology , antibiotics , biochemistry , antibiotic resistance , medicine , organic chemistry , finance , economics , enzyme
Skin and soft tissue infections are increasingly prevalent and often complicated by potentially fatal therapeutic hurdles, such as poor drug perfusion and antibiotic resistance. Delivery vehicles capable of versatile loading may improve local bioavailability and minimize systemic toxicities yet such vehicles are not clinically available. Therefore, we aimed to expand upon the use of glutathione-conjugated poly(ethylene glycol) GSH-PEG hydrogels beyond protein delivery and evaluate the ability to deliver traditional therapeutic molecules.