Open AccessThe Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke
Author(s) -
Pushkar Saralkar,
Alexander Mdzinarishvili,
Tasneem Arsiwala,
YoonKwang Lee,
Patrick G. Sullivan,
Mark V. Pinti,
John M. Hollander,
Eric E. Kelley,
Xuefang Ren,
Heng Hu,
James W. Simpkins,
Candice M. Brown,
Lori E Hazlehurst,
Jason D. Huber,
Werner J. Geldenhuys
Publication year - 2021
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-021-03046-4
Subject(s) - stroke (engine) , medicine , ischemia , in vivo , pharmacology , edema , oxidative stress , cerebral edema , anesthesia , mitochondrion , chemistry , biology , biochemistry , mechanical engineering , microbiology and biotechnology , engineering
Therapeutic strategies to treat ischemic stroke are limited due to the heterogeneity of cerebral ischemic injury and the mechanisms that contribute to the cell death. Since oxidative stress is one of the primary mechanisms that cause brain injury post-stroke, we hypothesized that therapeutic targets that modulate mitochondrial function could protect against reperfusion-injury after cerebral ischemia, with the focus here on a mitochondrial protein, mitoNEET, that modulates cellular bioenergetics.