Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier | Zendy

Ryuta Jomura | Zendy; Shinichi Akanuma | Zendy; Björn Bauer | Zendy; Yasuko Yoshida | Zendy; Yoshiyuki Kubo | Zendy; Kenichi Hosoya | Zendy

Open Access

Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier

Author(s) -

Ryuta Jomura,

Shinichi Akanuma,

Björn Bauer,

Yasuko Yoshida,

Yoshiyuki Kubo,

Kenichi Hosoya

Publication year - 2021

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-021-03003-1

Subject(s) - efflux , phenytoin , blood–brain barrier , p glycoprotein , pharmacology , transporter , chemistry , monocarboxylate transporter , anticonvulsant , in vivo , epilepsy , endocrinology , central nervous system , biology , biochemistry , neuroscience , multiple drug resistance , microbiology and biotechnology , antibiotics , gene

In this study, we investigated in detail the transport of phenytoin across the blood-brain barrier (BBB) to identify the transporter(s) involved in BBB-mediated phenytoin efflux from the brain.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research