Open AccessParticipation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier
Author(s) -
Ryuta Jomura,
Shinichi Akanuma,
Björn Bauer,
Yukiko Yoshida,
Yoshiyuki Kubo,
Kenichi Hosoya
Publication year - 2021
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-021-03003-1
Subject(s) - efflux , phenytoin , blood–brain barrier , p glycoprotein , pharmacology , transporter , chemistry , monocarboxylate transporter , anticonvulsant , in vivo , epilepsy , endocrinology , central nervous system , biology , biochemistry , neuroscience , multiple drug resistance , microbiology and biotechnology , antibiotics , gene
In this study, we investigated in detail the transport of phenytoin across the blood-brain barrier (BBB) to identify the transporter(s) involved in BBB-mediated phenytoin efflux from the brain.