Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans | Zendy

Yusuke Masuo | Zendy; Shushi Nagamori | Zendy; Aoi Hasegawa | Zendy; Kazuki Hayashi | Zendy; Noriyoshi Isozumi | Zendy; Noritaka Nakamichi | Zendy; Yoshikatsu Kanai | Zendy; Yukio Kato | Zendy

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Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans

Author(s) -

Yusuke Masuo,

Shushi Nagamori,

Aoi Hasegawa,

Kazuki Hayashi,

Noriyoshi Isozumi,

Noritaka Nakamichi,

Yoshikatsu Kanai,

Yukio Kato

Publication year - 2017

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-017-2140-4

Subject(s) - monoamine oxidase , chemistry , in vivo , pharmacology , microsome , substrate (aquarium) , monoamine neurotransmitter , in vitro , enzyme , biochemistry , serotonin , biology , receptor , ecology , microbiology and biotechnology

Monoamine oxidases (MAOs) are non-CYP enzymes that contribute to systemic elimination of therapeutic agents, and localized on mitochondrial membranes. The aim of the present study was to validate quantitative estimation of metabolic clearance of MAO substrate drugs using human liver microsomes (HLMs).

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