Revealing pMDI Spray Initial Conditions: Flashing, Atomisation and the Effect of Ethanol | Zendy

Nicholas Mason-Smith | Zendy; Daniel J. Duke | Zendy; Alan Kastengren | Zendy; Daniela Traini | Zendy; Paul M. Young | Zendy; Yang Chen | Zendy; David Lewis | Zendy; Daniel Edgington-Mitchell | Zendy; Damon Honnery | Zendy

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Revealing pMDI Spray Initial Conditions: Flashing, Atomisation and the Effect of Ethanol

Author(s) -

Nicholas Mason-Smith,

Daniel J. Duke,

Alan Kastengren,

Daniela Traini,

Paul M. Young,

Yang Chen,

David Lewis,

Daniel Edgington-Mitchell,

Damon Honnery

Publication year - 2017

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-017-2098-2

Subject(s) - nozzle , shadowgraphy , coalescence (physics) , propellant , analytical chemistry (journal) , materials science , chemistry , body orifice , mechanics , chromatography , thermodynamics , optics , organic chemistry , astrobiology , biology , ecology , laser , physics

Sprays from pressurised metered-dose inhalers are produced by a transient discharge of a multiphase mixture. Small length and short time scales have made the investigation of the governing processes difficult. Consequently, a deep understanding of the physical processes that govern atomisation and drug particle formation has been elusive.

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