Open AccessVinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer
Author(s) -
Ramakrishna Samala,
Helen R. Thorsheim,
Satyanarayana Goda,
Kunal S. Taskar,
Brunilde Gril,
Patricia S. Steeg,
Quentin R. Smith
Publication year - 2016
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-016-2012-3
Subject(s) - vinorelbine , medicine , brain metastasis , in vivo , breast cancer , metastasis , systemic administration , cancer , brain tumor , evans blue , pharmacokinetics , pharmacology , blood–brain barrier , pathology , biomarker , chemotherapy , central nervous system , chemistry , biology , cisplatin , biochemistry , microbiology and biotechnology
To evaluate vinorelbine drug exposure and activity in brain metastases of the human MDA-MB-231BR breast cancer model using integrated imaging and analysis.