Open AccessAbsorption and Clearance of Pharmaceutical Aerosols in the Human Nose: Effects of Nasal Spray Suspension Particle Size and Properties
Author(s) -
Alex D. Rygg,
Michael Hindle,
P. Worth Longest
Publication year - 2015
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-015-1837-5
Subject(s) - nasal spray , particle size , absorption (acoustics) , mucociliary clearance , nasal administration , drug delivery , chemistry , particle (ecology) , dissolution testing , drug , bioavailability , dosage form , pharmacokinetics , chromatography , biomedical engineering , pharmacology , materials science , medicine , organic chemistry , composite material , oceanography , biopharmaceutics classification system , lung , geology
The objective of this study was to use a recently developed nasal dissolution, absorption, and clearance (DAC) model to evaluate the extent to which suspended drug particle size influences nasal epithelial drug absorption for a spray product.