Chitosan Nanoparticles for the Linear Release of Model Cationic Peptide | Zendy

Anna Maria Piras | Zendy; Stefania Sandreschi | Zendy; Giuseppantonio Maisetta | Zendy; Semih Esin | Zendy; Giovanna Batoni | Zendy; Emo Chiellini | Zendy

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Chitosan Nanoparticles for the Linear Release of Model Cationic Peptide

Author(s) -

Anna Maria Piras,

Stefania Sandreschi,

Giuseppantonio Maisetta,

Semih Esin,

Giovanna Batoni,

Emo Chiellini

Publication year - 2015

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-014-1615-9

Subject(s) - chitosan , cationic polymerization , drug delivery , chemistry , active ingredient , peptide , nanoparticle , controlled release , combinatorial chemistry , biophysics , nanotechnology , chemical engineering , materials science , biochemistry , organic chemistry , pharmacology , medicine , engineering , biology

The present study is focused on the development of a model drug delivery system (DDS) based on Chitosan (CS) nanoparticles using Renin substrate I (RSI) as model agent. RSI shares the main chemical-physical features of several biologically active antimicrobial peptides (AMPs). AMPs have a great therapeutic potential that is hampered by their lability in the biological fluids and as such they are perfect candidates for DDS. The development studies of quality DDS loaded with AMPs would require highly sensitive and specific quantification assays. The use of RSI allowed for the fine-tuning and optimization of the formulation parameters to promote the hydrophobic interactions between CS and the cationic peptide, favour the loading of the active ingredient and enhance the release properties of the carrier.

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