Open AccessSignificantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method
Author(s) -
Tingting Yan,
Song Gao,
Xiaojuan Peng,
Jian Shi,
Cong Xie,
Qiang Li,
Linlin Lu,
Ying Wang,
Fuyuan Zhou,
Zhongqiu Liu,
Ming Hu
Publication year - 2014
Publication title -
pharmaceutical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 206
eISSN - 1573-904X
pISSN - 0724-8741
DOI - 10.1007/s11095-014-1525-x
Subject(s) - microsome , ugt2b7 , cyp3a4 , cytochrome p450 , drug metabolism , glucuronosyltransferase , gene isoform , hepatocellular carcinoma , chemistry , isozyme , uridine diphosphate , glucuronidation , xenobiotic , pharmacology , biochemistry , metabolism , enzyme , medicine , biology , gene
To determine the liver expression of cytochrome P450 (CYPs) and uridine 5'-diphosphate-glucuronosyltransferases (UGTs), the major phase I and II metabolism enzymes responsible for clearance and detoxification of drugs, xenobiotic and endogenous substances.