Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method | Zendy

TongMeng Yan | Zendy; Song Gao | Zendy; Xiaojuan Peng | Zendy; Jian Shi | Zendy; Cong Xie | Zendy; Qiang Li | Zendy; Linlin Lu | Zendy; Ying Wang | Zendy; Fuyuan Zhou | Zendy; Zhongqiu Liu | Zendy; Ming Hu | Zendy

Open Access

Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method

Author(s) -

TongMeng Yan,

Song Gao,

Xiaojuan Peng,

Jian Shi,

Cong Xie,

Qiang Li,

Linlin Lu,

Ying Wang,

Fuyuan Zhou,

Zhongqiu Liu,

Ming Hu

Publication year - 2014

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-014-1525-x

Subject(s) - microsome , ugt2b7 , cyp3a4 , cytochrome p450 , drug metabolism , glucuronosyltransferase , gene isoform , hepatocellular carcinoma , chemistry , isozyme , uridine diphosphate , glucuronidation , xenobiotic , pharmacology , biochemistry , metabolism , enzyme , medicine , biology , gene

To determine the liver expression of cytochrome P450 (CYPs) and uridine 5'-diphosphate-glucuronosyltransferases (UGTs), the major phase I and II metabolism enzymes responsible for clearance and detoxification of drugs, xenobiotic and endogenous substances.

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