A Model for Targeting Colon Carcinoma Cells Using Single-Chain Variable Fragments Anchored on Virus-Like Particles via Glycosyl Phosphatidylinositol Anchor | Zendy

Vipin Kumar Deo | Zendy; Megumi Yui | Zendy; Md Jahangir Alam | Zendy; Masahito Yamazaki | Zendy; Tatsuya Kato | Zendy; Enoch Y. Park | Zendy

Open Access

A Model for Targeting Colon Carcinoma Cells Using Single-Chain Variable Fragments Anchored on Virus-Like Particles via Glycosyl Phosphatidylinositol Anchor

Author(s) -

Vipin Kumar Deo,

Megumi Yui,

Md Jahangir Alam,

Masahito Yamazaki,

Tatsuya Kato,

Enoch Y. Park

Publication year - 2014

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-014-1316-4

Subject(s) - phosphatidylinositol , chemistry , spheroid , virus , chain (unit) , stereochemistry , virology , biology , microbiology and biotechnology , biophysics , biochemistry , in vitro , physics , signal transduction , astronomy

VLPs displaying tumor targeting single-chain variable fragments (VLP-rscFvs) which targets tumor-associated glycoprotein-72 (TAG-72) marker protein have a potential for immunotherapy against colon carcinoma tumors. In this study, scFvs anchored on VLPs using glycosylphosphatidylinositol (GPI) were prepared to target colon carcinoma spheroids in vitro.

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