CriticalSorb™ Promotes Permeation of Flux Markers Across Isolated Rat Intestinal Mucosae and Caco-2 Monolayers | Zendy

David J. Brayden | Zendy; Victoria A Bzik | Zendy; Andrew L. Lewis | Zendy; Lisbeth Illum | Zendy

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CriticalSorb™ Promotes Permeation of Flux Markers Across Isolated Rat Intestinal Mucosae and Caco-2 Monolayers

Author(s) -

David J. Brayden,

Victoria A Bzik,

Andrew L. Lewis,

Lisbeth Illum

Publication year - 2012

Publication title -

pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 206

eISSN - 1573-904X

pISSN - 0724-8741

DOI - 10.1007/s11095-012-0785-6

Subject(s) - paracellular transport , caco 2 , transcellular , mannitol , chemistry , in vitro , ussing chamber , permeation , pharmacology , biochemistry , biology , membrane , permeability (electromagnetism)

CriticalSorb™ is a novel absorption enhancer based on Solutol(®) HS15, one that has been found to enhance the nasal transport. It is in clinical trials for nasal delivery of human growth hormone. The hypothesis was that permeating enhancement effects of the Solutol(®)HS15 component would translate to the intestine.

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