Heterogeneity of radiation response in mesenchymal subtype glioblastoma: molecular profiling and reactive oxygen species generation | Zendy

Christopher P. Cifarelli | Zendy; Angelica Jacques | Zendy; Andrey A. Bobko | Zendy

Open Access

Heterogeneity of radiation response in mesenchymal subtype glioblastoma: molecular profiling and reactive oxygen species generation

Author(s) -

Christopher P. Cifarelli,

Angelica Jacques,

Andrey A. Bobko

Publication year - 2021

Publication title -

journal of neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.256

H-Index - 114

eISSN - 1573-7373

pISSN - 0167-594X

DOI - 10.1007/s11060-021-03707-9

Subject(s) - clonogenic assay , mesenchymal stem cell , cancer research , in vivo , radiation sensitivity , radiation therapy , biology , chemistry , microbiology and biotechnology , medicine , irradiation , genetics , nuclear physics , physics

Radiotherapy-induced tumor death remains critical in the successful first-line management of glioblastoma, whereas resistance to radiation serves as a major factor in disease progression. Mesenchymal shift has been identified as a driver in GBM recurrence, with gene expression associated with enhanced repair of macromolecular damage caused by radiation.

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