Open AccessHeterogeneity of radiation response in mesenchymal subtype glioblastoma: molecular profiling and reactive oxygen species generation
Author(s) -
Christopher P. Cifarelli,
Angelica Jacques,
Andrey A. Bobko
Publication year - 2021
Publication title -
journal of neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.256
H-Index - 114
eISSN - 1573-7373
pISSN - 0167-594X
DOI - 10.1007/s11060-021-03707-9
Subject(s) - clonogenic assay , mesenchymal stem cell , cancer research , in vivo , radiation sensitivity , radiation therapy , biology , chemistry , microbiology and biotechnology , medicine , irradiation , genetics , nuclear physics , physics
Radiotherapy-induced tumor death remains critical in the successful first-line management of glioblastoma, whereas resistance to radiation serves as a major factor in disease progression. Mesenchymal shift has been identified as a driver in GBM recurrence, with gene expression associated with enhanced repair of macromolecular damage caused by radiation.