Open AccessTargeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma
Author(s) -
Jacquelyn T Saunders,
Brent Holmes,
Angelica Benavides-Serrato,
Sunil Kumar,
Robert N. Nishimura,
Joseph Gera
Publication year - 2021
Publication title -
journal of neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.256
H-Index - 114
eISSN - 1573-7373
pISSN - 0167-594X
DOI - 10.1007/s11060-021-03699-6
Subject(s) - hippo signaling pathway , cancer research , glioblastoma , downregulation and upregulation , biology , yap1 , transcription factor , effector , foxm1 , microbiology and biotechnology , genetics , gene
Recent studies have suggested that dysregulated Hippo pathway signaling may contribute to glioblastoma proliferation and invasive characteristics. The downstream effector of the pathway, the Yes-associated protein (YAP) oncoprotein, has emerged as a promising target in glioblastoma multiforme (GBM).