Open AccessDetection of glioblastoma intratumor heterogeneity in radiosensitivity using patient-derived neurosphere cultures
Author(s) -
Joseph H. McAbee,
Charlotte Degorre-Kerbaul,
Kristin Valdez,
Astrid Wendler,
Uma Shankavaram,
Colin Watts,
Kevin Camphausen,
Philip J. Tofilon
Publication year - 2020
Publication title -
journal of neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.256
H-Index - 114
eISSN - 1573-7373
pISSN - 0167-594X
DOI - 10.1007/s11060-020-03643-0
Subject(s) - radiosensitivity , cell culture , biology , glioblastoma , cancer research , brain tumor , radiation therapy , pathology , medicine , genetics
Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degrees of radiosensitivity has not been established.