Open AccessVisualization technologies for 5-ALA-based fluorescence-guided surgeries
Author(s) -
Linpeng Wei,
David W. Roberts,
Nader Sanai,
Jonathan Liu
Publication year - 2018
Publication title -
journal of neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.256
H-Index - 114
eISSN - 1573-7373
pISSN - 0167-594X
DOI - 10.1007/s11060-018-03077-9
Subject(s) - visualization , glioma , biomedical engineering , computer science , resection , fluorescence microscope , medical physics , medicine , artificial intelligence , fluorescence , surgery , cancer research , optics , physics
5-ALA-based fluorescence-guided surgery has been shown to be a safe and effective method to improve intraoperative visualization and resection of malignant gliomas. However, it remains ineffective in guiding the resection of lower-grade, non-enhancing, and deep-seated tumors, mainly because these tumors do not produce detectable fluorescence with conventional visualization technologies, namely, wide-field (WF) surgical microscopy.