Open AccessNovel piRNA MW557525 regulates the growth of Piwil2-iCSCs and maintains their stem cell pluripotency
Author(s) -
Liming Jin,
Zhaoxia Zhang,
Zhang Wang,
Xiaojun Tan,
Zhaoying Wang,
Lianju Shen,
Chunlan Long,
Guanghui Wei,
Dalin He
Publication year - 2022
Publication title -
molecular biology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 71
eISSN - 1573-4978
pISSN - 0301-4851
DOI - 10.1007/s11033-022-07443-9
Subject(s) - piwi interacting rna , sox2 , gene knockdown , biology , klf4 , microbiology and biotechnology , cell growth , stem cell , gene , genetics , rna interference , rna , transcription factor
CSCs play an important role in tumor development. Some studies have demonstrated that piRNAs participate in the progression of various cancers. However, the detailed function of piRNAs in CSCs requires further investigation. This study aimed to investigate the significance of novel piRNA MW557525, one of the top five up-regulated piRNAs screened by gene chip and it has been verified by RT-q-PCR that it is indeed the most obvious up-regulated expression in Piwil2-iCSCs.