Open AccessDependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer
Author(s) -
Aarifa Nazmeen,
Guangping Chen,
Smarajit Maiti
Publication year - 2020
Publication title -
molecular biology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 71
eISSN - 1573-4978
pISSN - 0301-4851
DOI - 10.1007/s11033-020-05518-z
Subject(s) - estrogen , breast cancer , oxidative stress , transcription factor , estrogen receptor , carcinogenesis , sulfotransferase , cancer , biology , cancer research , medicine , endocrinology , chemistry , enzyme , gene , genetics , biochemistry
Human estrogen sulfotransferase (SULT1E1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression influences each other in advanced human breast carcinogenesis. The difference in the metabolism of estradiol (E2) in pre- and post-menopausal women remains to be connected with post-menopausal breast cancer. A synergism between ROS production and E2 generation has been demonstrated. No definite mechanism for simultaneous functions of Nrf2, oxidative stress E2 regulating enzymes (SULT1E1) has been yet clarified. Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression. This study also focuses the idea that estrogen receptor cased subtypes of cancer may have different molecular environments which has an impact on the therapeutic efficacy.