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Clinical Cancer Genetics Disparities among Latinos
Author(s) -
CruzCorrea Marcia,
PérezMayoral Julyann,
Dutil Julie,
Echenique Miguel,
Mosquera Rafael,
RiveraRomán Keila,
Umpierre Sharee,
RodriguezQuilichini Segundo,
GonzalezPons Maria,
Olivera Myrta I.,
Pardo Sherly
Publication year - 2017
Publication title -
journal of genetic counseling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 52
eISSN - 1573-3599
pISSN - 1059-7700
DOI - 10.1007/s10897-016-0051-x
Subject(s) - genetic counseling , latin americans , medicine , lynch syndrome , cancer , genetic testing , human genetics , cancer genetics , public health , health equity , cancer prevention , family medicine , cancer screening , gerontology , colorectal cancer , genetics , pathology , biology , political science , dna mismatch repair , gene , law
The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture‐based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.