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Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System
Author(s) -
Cameron L. Gardner,
Mara Pavel-Dinu,
Kerry Dobbs,
Marita Bosticardo,
Paul K. Reardon,
Justin Lack,
Suk See De Ravin,
Kent Le,
Ezekiel Bello,
Francesca Pala,
Ottavia M. Delmonte,
Harry L. Malech,
Amelie Montel-Hagan,
Gay M. Crooks,
Oreste Acuto,
Matthew H. Porteus,
Luigi D. Notarangelo
Publication year - 2021
Publication title -
journal of clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.739
H-Index - 96
eISSN - 1573-2592
pISSN - 0271-9142
DOI - 10.1007/s10875-021-00989-6
Subject(s) - induced pluripotent stem cell , recombination activating gene , biology , stem cell , immune system , immunology , severe combined immunodeficiency , rag2 , immunodeficiency , transplantation , genome editing , hematopoietic stem cell transplantation , t cell , microbiology and biotechnology , embryonic stem cell , gene , medicine , genetics , crispr , recombination

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