Open AccessInfections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers
Author(s) -
Morna J. Dorsey,
Nicola Wright,
Natalia S. Chaimowitz,
Blachy J. Dávila Saldaña,
Holly Miller,
Michael D. Keller,
Monica S. Thakar,
Ami J. Shah,
Rolla AbuArja,
Jeffrey Andolina,
Victor Aquino,
Jessie L. Barnum,
Jeffrey J. Bednarski,
Monica Bhatia,
Francisco A. Bonilla,
Manish J. Butte,
Nancy Bunin,
Sharat Chandra,
Sonali Chaudhury,
Karin Chen,
Hey Chong,
Geoffrey D.E. Cuvelier,
Jignesh Dalal,
Magee L. DeFelice,
Kenneth DeSantes,
Lisa R. Forbes,
Alfred P. Gillio,
Fred Goldman,
Avni Y. Joshi,
Neena Kapoor,
Alan P. Knutsen,
Lisa Kobrynski,
Jay Lieberman,
Jennifer W. Leiding,
Benjamin Oshrine,
Kiran Patel,
Susan E. Prockop,
Troy C. Quigg,
Ralph Quis,
Kirk R. Schultz,
Christine M. Seroogy,
David C. Shyr,
Subhadra Siegel,
Angela R. Smith,
Troy R. Torgerson,
Mark T. Vander Lugt,
Lolie C. Yu,
Morton J. Cowan,
Rebecca H. Buckley,
Christopher C. Dvorak,
Linda M. Griffith,
Élie Haddad,
Donald B. Kohn,
Brent R. Logan,
Luigi D. Notarangelo,
Sung Yun Pai,
Jennifer M. Puck,
Michael A. Pulsipher,
Jennifer Heimall
Publication year - 2020
Publication title -
journal of clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.739
H-Index - 96
eISSN - 1573-2592
pISSN - 0271-9142
DOI - 10.1007/s10875-020-00865-9
Subject(s) - medicine , newborn screening , hematopoietic stem cell transplantation , pediatrics , medical microbiology , isolation (microbiology) , natural history , retrospective cohort study , primary immunodeficiency , severe combined immunodeficiency , transplantation , intensive care medicine , immunology , disease , biochemistry , chemistry , gene , microbiology and biotechnology , biology
The Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children with severe combined immunodeficiency (SCID) in a prospective natural history study of hematopoietic stem cell transplant (HSCT) outcomes over the last decade. Despite newborn screening (NBS) for SCID, infections occurred prior to HSCT. This study's objectives were to define the types and timing of infection prior to HSCT in patients diagnosed via NBS or by family history (FH) and to understand the breadth of strategies employed at PIDTC centers for infection prevention.