Open AccessInherited CARD9 Deficiency in a Patient with Both Exophiala spinifera and Aspergillus nomius Severe Infections
Author(s) -
Laura Pérez,
Fernando Messina,
Ricardo Negroni,
Alicia Arechavala,
Jacinta Bustamante,
Matías Oleastro,
Mélanie Migaud,
JeanLaurent Casanova,
Anne Puel,
Gabriela Santiso
Publication year - 2020
Publication title -
journal of clinical immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.739
H-Index - 96
eISSN - 1573-2592
pISSN - 0271-9142
DOI - 10.1007/s10875-019-00740-2
Subject(s) - caspofungin , posaconazole , aspergillus , immunology , phaeohyphomycosis , medical microbiology , chronic granulomatous disease , aspergillosis , biology , medicine , microbiology and biotechnology , voriconazole , antifungal
Caspase-associated recruitment domain-9 (CARD9) deficiency is an inborn error of immunity that typically predisposes otherwise healthy patients to single fungal infections and the occurrence of multiple invasive fungal infections is rare. It has been described as the first known condition that predisposes to extrapulmonary Aspergillus infection with preserved lungs. We present a patient that expands the clinical variability of CARD9 deficiency.