Open AccessO-GlcNAcylation: key regulator of glycolytic pathways
Author(s) -
Zachary A. Bacigalupa,
Chaitali H. Bhadiadra,
Mauricio J. Reginato
Publication year - 2018
Publication title -
journal of bioenergetics and biomembranes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.09
H-Index - 97
eISSN - 1573-6881
pISSN - 0145-479X
DOI - 10.1007/s10863-018-9742-3
Subject(s) - regulator , glycolysis , microbiology and biotechnology , key (lock) , metabolic pathway , biology , bioorganic chemistry , metabolism , biochemistry , chemistry , enzyme , gene , ecology
Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.