Open AccessPotential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve
Author(s) -
Zexu Jiao,
Orhan Bükülmez
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-021-02246-6
Subject(s) - reproductive medicine , infertility , ovarian reserve , assisted reproductive technology , fertility preservation , reproductive technology , in vitro fertilisation , reproductive endocrinology and infertility , gynecology , fertility , female infertility , medicine , oncofertility , andrology , physiology , biology , pregnancy , environmental health , population , genetics , lactation
In assisted reproductive technology treatment, diminished ovarian reserve (DOR) is a condition of utmost clinical and scientific relevance because of its negative influence on patient outcomes. The current methods of infertility treatment may be unsuitable for many women with DOR, which support the need for development of additional approaches to achieve fertility restoration. Various techniques have been tried to improve the quality and increase the quantity of oocytes in DOR patients, including mitochondrial transfer, activation of primordial follicles, in vitro culture of follicles, and regeneration of oocytes from various stem cells. Herein, we review the science behind these experimental reproductive technologies and their potential use to date in clinical studies for infertility treatment in women with DOR.