Open AccessAssociation of CPT1A gene polymorphism with the risk of gestational diabetes mellitus: a case-control study
Author(s) -
Q W Ren,
Mengzhu Guo,
Feifei Yang,
Tianbi Han,
Wenqiong Du,
Feng Zhao,
Jinbo Li,
Wangjun Li,
Yongliang Feng,
Suping Wang,
Yawei Zhang,
Weiwei Wu
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-021-02143-y
Subject(s) - gestational diabetes , single nucleotide polymorphism , biology , haplotype , insulin resistance , candidate gene , medicine , endocrinology , pregnancy , case control study , diabetes mellitus , genetics , allele , gene , genotype , gestation
Gestational diabetes mellitus (GDM) is a growing public health problem worldwide and its etiology remains unclear. The pathophysiology of GDM is similar to that of type 2 diabetes (T2DM) and insulin resistance (IR) is the main reason for the development of GDM. Carnitine palmitoyltransferase 1A (CPT1A) is a candidate gene for metabolic disorders; however, the association of the CPT1A gene and GDM has not yet been studied. We aimed to explore whether single-nucleotide polymorphisms (SNPs) of the CPT1A gene could influence the risk of GDM.