Open AccessOutcome prediction of microdissection testicular sperm extraction based on extracellular vesicles piRNAs
Author(s) -
Haicheng Chen,
Yun Xie,
Yanqing Li,
Chi Zhang,
Linyan Lv,
Jiahui Yao,
Chunhua Deng,
Xiangzhou Sun,
Xueg Zou,
Guihua Liu
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-021-02101-8
Subject(s) - sperm , logistic regression , andrology , biology , testicular sperm extraction , extracellular vesicles , cohort , azoospermia , microdissection , intracytoplasmic sperm injection , medicine , in vitro fertilisation , embryo , genetics , infertility , microbiology and biotechnology , pregnancy , gene
Microdissection testicular sperm extraction (micro-TESE) could retrieve sperm from the testicles to help the non-obstructive azoospermia (NOA) patients to get their biological children, but also would cause damage to the testicles. Therefore, it is necessary to preoperatively predict the micro-TESE outcome in NOA patients. For this purpose, we aim to develop a model based on extracellular vesicles' (EVs) piRNAs (EV-piRNAs) in seminal plasma.