Open AccessRisks of nonchromosomal birth defects, small-for-gestational age birthweight, and prematurity with in vitro fertilization: effect of number of embryos transferred and plurality at conception versus at birth
Author(s) -
Barbara Luke,
Morton B. Brown,
Ethan Wantman,
Nina Forestieri,
Marilyn L. Browne,
Sarah C. Fisher,
Mahsa M. Yazdy,
Mary K. Ethen,
Mark A. Canfield,
Hazel B. Nichols,
Sergio Oehninger,
Kevin J. Doody,
Alastair Sutcliffe,
Charles S. Williams,
Michael L. Eisenberg,
Valerie L. Baker,
Caitlin R. Sacha,
Philip J. Lupo
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-021-02095-3
Subject(s) - obstetrics , small for gestational age , odds ratio , medicine , gestational age , gestation , birth weight , live birth , premature birth , low birth weight , in vitro fertilisation , pregnancy , biology , genetics
Excess embryos transferred (ET) (> plurality at birth) and fetal heartbeats (FHB) at 6 weeks' gestation are associated with reductions in birthweight and gestation, but prior studies have been limited by small sample sizes and limited IVF data. This analysis evaluated associations between excess ET, excess FHB, and adverse perinatal outcomes, including the risk of nonchromosomal birth defects.