Open AccessDeregulation of imprinted genes expression and epigenetic regulators in placental tissue from intrauterine growth restriction
Author(s) -
Carla Caniçais,
Sara Vasconcelos,
Carla Ramalho,
C. Joana Marques,
Sofia Dória
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-02047-3
Subject(s) - epigenetics , dna methylation , genomic imprinting , biology , dnmt3b , intrauterine growth restriction , imprinting (psychology) , bisulfite sequencing , methylation , regulation of gene expression , methylated dna immunoprecipitation , genetics , andrology , gene expression , gene , fetus , medicine , pregnancy
Intrauterine growth restriction (IUGR) is a fetal growth complication that can be caused by ineffective nutrient transfer from the mother to the fetus via the placenta. Abnormal placental development and function have been correlated with abnormal expression of imprinted genes, which are regulated by epigenetic modifications at imprinting control regions (ICRs). In this study, we analyzed the expression of imprinted genes known to be involved in fetal growth and epigenetic regulators involved in DNA methylation, as well as DNA methylation at the KvDMR1 imprinting control region and global levels of DNA hydroxymethylation, in IUGR cases.