Open AccessY chromosome structural variation in infertile men detected by targeted next-generation sequencing
Author(s) -
Xiangyin Liu,
Han Zhang,
Xinyue Zhang,
Hongguo Zhang,
Yuting Jiang,
Ruizhi Liu,
Fei Jia,
Ying Wang,
Yang Yu
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-02031-x
Subject(s) - azoospermia factor , copy number variation , male infertility , structural variation , y chromosome microdeletion , biology , genetics , y chromosome , sequence tagged site , azoospermia , infertility , chromosome , dna sequencing , semen , gene duplication , gene , genome , gene mapping , pregnancy
To provide a validated method to identify copy number variation (CNV) in regions of the Y chromosome of infertile men by next-generation sequencing (NGS).